This important study (Sullivan et al) examines the relationship between disc calcification (measured by K-number/K-n) and the FGF4L2 gene in Dachshunds. Here are the key findings from the analysis of a sample of Norwegian and Finnish Dachshunds:
Genetics and Disc Health:
– Dachshunds with one normal copy of the gene (N/FGF4L2) have significantly better spinal health than those with two copies of FGF4L2
– 75% of dogs with one normal copy had the best possible score (K0)
– 98% of dogs with at least one normal copy had low-risk scores (K0-K2)
– Only 1% of dogs with one normal copy had high-risk scores (K5+)
– Breeding dogs with one normal copy (N/FGF4L2) is likely to produce puppies with better spinal health
– Both K-number and FGF4L2 status should be considered when choosing breeding stock
– Given the gene’s high frequency in Dachshunds, aiming for one normal copy is more practical than trying to breed for two normal copies
– K0: ~7% risk of disc disease
The researchers recommend developing breeding strategies that prioritise dogs with at least one normal copy of the gene, while using K-number scores to help select among dogs with two copies of FGF4L2.
